Guggulsterone Supplements Information: Guggulsterones are beneficial compounds derived from a traditional Ayurvedic medicinal plant preparation called guggul, a gummy resin collected from the small Commiphora mukul tree. The two primary types thought to be responsible for gugglsterones' effects are Z-Guggulsterone and E-Guggulsterone.
Guggulsterone's Health Benefits:
Guggulsterones may be able to support healthy cholesterol levels and cardiovascular health.1,2 Some animal studies suggest guggulsterones may also benefit conditions like hypothyroidism in humans.3
Using Guggulsterone Supplements:
Use as directed.
Side-effects and Cautions:
Guggul may cause stomach discomfort or allergic rash as well as other serious side effects and interactions. It should be avoided in pregnant or breast-feeding women and in children. Safety of use beyond 4 months has not been well studied.
Additional Information: Guggulsterone is from the guggul plant (not to be confused with everyone’s favorite search engine, the herbal plant name for it is Commiphora Mukul).
Guggulsterones are made up of two different stereoisomers ((a stereoisomer is an isomeric molecule where atomic connectivity is the same, but the location of the atoms is different - just in case you really cared for some reason)), E and Z. That’s all the E and Z mean. You might see it represented like this: “GuggulEZ” (this is what Thincinerator does) or “Guggulsterones EZ” but it’s all the same thing.
There are two basic processing methods for guggul, one produces low-potency and the other high-potency. Naturally, every diet pill company including guggulsterones in some form claims that they use the high-potency method.
Unfortunately, the only way to verify it is to open a capsule (meaning you already had to purchase it, and it won’t be returnable according to most diet pill company return policies) and see if it’s brown or yellow.
Brown = High Potency | Yellow = Low Potency
Health Benefits: Guggulsterones - Supports Cholesterol Wellness! Guggulsterones help maintain cholesterol levels already in the normal range, by acting at the farnesoid X receptor (FXR) to promote the conversion of cholesterol into bile. They also boost thyroid activity, which supports cholesterol regulation by the liver.
Cholesterol reduction - It is well established that orally administered guggulipid decreases LDL cholesterol and triglyceride (TG) levels while either having no effect on or slightly increasing HDL cholesterol levels. Depending on dosage, it generally reduces LDL and TG levels between 10 to 25 percent.
Anti-inflammatory - Guggulipid is a potent anti-inflammatory agent, as evidenced by many studies done on individuals with arthritis. The compound primarily responsible for the anti-inflammatory properties of guggul is myrrhanol A, which is found in the acidic fraction of the extract.
Reduction in acne - There are many anecdotal reports of guggul causing a reduction of acne. There has been only one clinical study done, in which guggul was shown to be as effective as tetracycline (an antibiotic commonly used to treat acne).
Reduced oxidative stress - Guggulipid may significantly decrease lipid peroxidation. One controlled study showed a 33% decrease in lipid peroxides after 24 weeks of 50 mg of guggulipid per day.