What is Pyridoxal 5-Phosphate?
Pyridoxal 5-Phosphate (P-5-P) is the active form of the essential vitamin B6, Pyridoxine.
This form of Vitamin B6 is the active form. Vitamin B6 must be converted by the liver into Pyridoxal 5-Phosphate before it is active in the body. Some people do not do this well. This active form of Vitamin B6 is 10 times more effective than Pyridoxine when it is indicated.
High doses of Pyridoxine cause numbness or tingling in the extremities. This is thought to occur when the body does not convert Pyridoxine to Pyridoxal 5-Phosphate very efficiently.
Vitamin B6 is required in amino acid metabolism, sphingolipid biosynthesis and degradation, heme biosynthesis, neurotransmitter biosynthesis, collagen formation and glucocorticoid action.
In order for vitamins to be utilized by the body, they must first be converted into their active coenzyme forms. The active form of Vitamin B-6 is Pyridoxal-5-phosphate or P5P, this active form allows for the best absorption, because it is ready to go to work immediately.
It is primarily in the liver that P5P is synthesized from pyridoxine with the help of enzymes this requires Vitamin B2, zinc and magnesium for their activity. P5P is associated with numerous enzymes, many of which are involved in amino acid metabolism. This necessary process produces the neurotransmitters dopamine, nor adrenalin, GABA and cartooning, as well as the hemoglobin in red blood cells.
Many B6 supplements are the inactive pyridoxine HCL form. In some cases supplementation of this form singularly, caused a reversible numbness & tingling of the extremities. In doses as low as 200 mg daily over a 3-year period. This problem was thought to be secondary to the liver's inability to convert this form into the useable P5P form. Using P5P avoids this problem.
It's the P5P our bodies really need to break down and use fats, proteins, and carbohydrates, to make red blood cells and antibodies, to help the digestive and nervous systems function, and to maintain healthy skin.
But some folks have trouble-converting pyridoxine into P5P. Those susceptible to a deficiency include some breast-fed infants, elderly persons on a poor diet, and women on estrogen-containing oral contraceptive pills. B6 has recently been found to benefit the autistic and is thought the P5P form may even provide more benefit.
Also, people such as: pregnant and nursing mothers, the elderly, the autistic, and babies at risk of SIDS (Sudden Infant Death Syndrome). P5P is the only form of B6 that the fetus and newborn baby can use. In premature babies, who are more susceptible than full-term babies to SIDS, the use of the pyridoxine form of B6 can result in irreversible central nervous system damage.
And lack of P5P can predispose a surviving premature infant to atherosclerosis in later life. In addition, the fact that B6 benefits some persons with Carpal Tunnel Syndrome, and not others, we think may well be traced to the person's ability or inability to make P5P from pyridoxine.
SYMPTOMS OF DEFICIENCY:
Poor dream recall
Cracks around mouth & eyes
Dermatitis & acne
Stillbirths from deficiency during pregnancy
Decreased vitamin C levels
Increased sensitivity to sound
Decreased resistance to infection
Impaired wound healing
Impaired calcium utilization
Decreased absorption of copper
Decreased iron status
Decreased Vitamin B 12 absorption
Carpal tunnel syndrome
Temporary limb paralysis
Numbness & tingling in the limbs
Elevated homocysteine levels
Low blood sugar
Low glucose tolerance
PYRIDOXAL-5-PHOSPHATE BENEFITS INCLUDE:
Helping to relieve premenstrual syndrome.
Useful with carpal-tunnel syndrome.
Helps boost immunity.
Is protective against atherosclerosis.
May be protective against forms of cancer.
Food Science's Pyridoxal-5-Phosphate
Douglas Lab's Pyridoxal 5-Phosphate