Synephrine can be found in the fruit of a plant known as Citrus aurantium. It is one of the main active compounds found in the fruit and is also known as green orange, or zhi shi in Chinese. It is also called sour orange or bitter orange in other parts of the world.
Chemically speaking, synephrine is chemically similar to the pseudo-ephedrine and ephedrine compounds that can be located in many of the over-the-counter cold and allergy medications. It is also found in a variety of weight loss and energy supplements that contain Ma Huang.
What are the benefits of taking synephrine?
Those that use synephrine claim a myriad of benefits. This can include increasing metabolic rates, an increase of caloric expenditure (the quickness in which you lose calories), increasing of energy levels, as well as synephrine acting as a fat burner and as a promoter of weight loss.
The theory is that because synephrine acts as a stimulant, much like caffeine, it is believed to have some of the same effects in terms of an energy boost, as well as increasing metabolic rates and suppressing appetites. In Chinese medicine, zhi shi is used to help stimulate energy. While synephrine and many of the components that can be found in zhi shi appear to be the same as the ones found in ephedrine, synephrine is believed to work as a stimulant without leaving the negative side effects that inflict the central nervous system like ephedra does.
Zhi shi is also believed to help stimulate the metabolism in your body without the negative cardiovascular side effects that are experienced by at least some people that take ephedra. This is through its stimulation through specific adrenergic receptors, including beta-3 (not 1 or 2).
Who can benefit from taking synephrine?
Those that are looking to lose weight or increase their energy can possibly reap the benefits from supplementing with synephrine. However, those that have cardiovascular problems should not take synephrine – more on potential side effects are listed below.
How much synephrine should I take?
A typical dose of 4-20 mg of synephrine daily can be found suggested by products providing the standardized citrus aurantium extract of 200-600mg per pill. These contain about 3-6% of synephrine. Of course, you should always follow the label directions found on the package of the supplement.
Does synephrine have any side effects?
Synephrine, as well as citrus aurantium extract have shown in animal studies to raise blood pressure. More studies are needed to prove or disprove the same effect in humans. It is recommended that while studies on the efficacy, safety, and pharmacology of citrum aurantium as a thermogenic supplement are still being performed, you should treat the substance as supplement with tame stimulant properties. As such, it should be avoided by individuals with cardiovascular-related inflictions, like hypertension.